Interferon-g-Inducible Protein 10 for Diagnosis of Tuberculosis in Children
نویسندگان
چکیده
منابع مشابه
Potential of interferon-γ-inducible protein 10 in improving tuberculosis diagnosis in HIV-infected patients.
In patients latently infected with Mycobacterium tuberculosis, immunosuppression significantly augments the risk of progression to active tuberculosis (TB) and TB is still one of the most frequent opportunistic infections worldwide. Prevention of TB in HIV-positive patients using the tuberculin skin testing (TST) followed by targeted preventive treatment is an effective strategy, but has thus f...
متن کاملElevated Levels of Interferon-inducible Protein-10 (IP)-10/CXCL10, but not of Interferon-γ, in Patients with Pulmonary Tuberculosis
Mycobacterial strains are potent inducers of cytokines/chemokines by mononuclear phagocytes, which constitute an important cellular component of the first line of defense in the innate immune system. Interferon (IFN)-γ-inducible protein (IP-10 or CXCL10) is a potent chemoattractant; however, little is known about the IP-10 profiles attributable to the Th1 regulation associated with active tuber...
متن کاملA Comparison of Interferon-g and IP-10 for the Diagnosis of Tuberculosis
OBJECTIVE: Interferon-g and IP-10 release assays are diagnostic tests for tuberculosis infection. We have compared the accuracy of IP-10 and QuantiFERON-TB Gold In-tube [QFT-IT] in Tanzanian children suspected of having active tuberculosis (TB). METHODS: Hospitalized Tanzanian children with symptoms of TB were tested with the QFT-IT and IP-10 tests and retrospectively classified into diagnostic...
متن کاملRole of QuantiFERON-TB Gold, Interferon Gamma Inducible Protein-10 and Tuberculin Skin Test in Active Tuberculosis Diagnosis
BACKGROUND The measurement of Interferon gamma or Interferon gamma inducible protein (IP)-10 in antigen stimulated blood samples is suggested as an alternative method for latent tuberculosis (TB) diagnosis. Nonetheless, their role in active TB diagnosis, particularly in TB endemic settings is yet to be defined. In this study, the sensitivities and specificities of Interferon gamma release assay...
متن کاملHuman Interferon-γ–inducible Protein 10 (IP-10) Inhibits Constitutive Signaling of Kaposi's Sarcoma–associated Herpesvirus G Protein–coupled Receptor
A G protein-coupled receptor (GPCR) is encoded within the genome of Kaposi's sarcoma- associated herpesvirus (KSHV)/human herpesvirus 8, a virus that may be involved in the pathogenesis of Kaposi's sarcoma and primary effusion lymphomas. KSHV-GPCR exhibits constitutive signaling activity that causes oncogenic transformation. We report that human interferon (IFN)-gamma-inducible protein 10 (HuIP...
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ژورنال
عنوان ژورنال: The Indonesian Biomedical Journal
سال: 2020
ISSN: 2355-9179,2085-3297
DOI: 10.18585/inabj.v12i1.973